Some of these might be a little more like 8 than 5 because they have storybook-scary but still mentioning for you to have a look and decide.

Lost Words - Beyond the Page
Unpacking
Epistory - Typing Chronicles
One Step from Eden
Wargroove
Tsioque

Technically not female lead but kinda close and definitely age-appropriate:

Chicory - From creators on Wandersong + Celeste. Not positive your character is canonically female but let’s just call it very plausible and you are filling in for the titular character who is called “she”.
Donut County (technically the male racoon is the main character but the only human and next-most important character is female)
Journey (likely canonically no specific gender but great game, no dialog and could easily interpret as female if you choose)

Not what you asked for but maybe consider:

Beglitched - No human characters other than the player, puzzle game with pink and purple hacker aesthetic.
Lovers in a Dangerous Spacetime - Androgynous animals and humans pilot a wacky ship in 4 player co-op lots of hearts.