You can’t do that with Pihole as the ads come from the same domains, and basically need a browser extension or an app with a built in equivalent.
If you’re in the UK though, it does block the ads on All4 which was a nice surprise. It even works for the TV app.
I just switched from Pop!_OS to openSUSE, but not through any fault of Pop. I really liked it in fact, and it was great to have a distro to show me out of the box what was possible on other distros after a bit of configuration. It’s certainly tempting me to get a System76 laptop.