Fallout: New Vegas.

You can kill Caesar, the scourge of the wasteland, and hardly anybody notices. Like, Jesus Christ, Hitler died so long ago and he still casts the shadow upon our society at large, but somehow strangling his local counterpart equals to no real effect.

Uncharted Waters. The game was gridded, and you could not move through them, so it was fairly common to get stuck in a doorway or otherwise get impeded by them.

They also contributed little asides flavor, so there was no real point in talking to them.